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KMID : 1001920180610030312
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Journal of Korean Neurosurgical Society
2018 Volume.61 No. 3 p.312 ~ p.318
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Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
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Jung Tae-Young
Jung Shin
Kook Hoon
Baek Hee-Jo
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Abstract
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Surgery and radiotherapy are mainstays of treatment for ependymomas (EPNs). Recent molecular subgrouping could be superior to histopathological grading for predicting the prognosis of patients with EPNs. Gross total resection is an effective treatment approach regardless of its locations or pathologic grades. Adjuvant therapeutic strategies could be decided based on molecular subgrouping with risk-stratification. Information of histologic-molecular biology is now providing clues to therapeutic insights.
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KEYWORD
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Ependymoma, Biology, Molecular medicine, Therapeutics
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